ea0007p104 | Endocrine tumours and neoplasia | BES2004
Khalaf S
, Bailey F
, Davies D
, Ogunkolade B
, Kelly P
, McCarthy K
, Laban C
, Bustin S
, Jenkins P
Introduction: Somatostatin and its analogues (SSA) have been reported to have anti-proliferative effects. We have recently demonstrated expression of all 5 somatostatin receptor sub-types in normal and malignant colonic tissue. SOM-230 (Novartis) is a novel SSA that has a wider binding affinity to somatostatin receptors compared to octreotide (OCT). Its effects on proliferation of colonic cancer cells are unknown.Aims: To determine the effects of SOM-230...